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KMID : 1147720090020020118
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Journal of Acupuncture and Meridian Studies
2009 Volume.2 No. 2 p.118 ~ p.123
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Bonghan Ducts as Possible Pathways for Cancer Metastasis
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Yoo Jung-Sun
Kim Hong-Bae
Ogay Vyacheslav
Lee Byung-Cheon
Ahn Sae-Young
Soh Kwang-Sup
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Abstract
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Objective: The present study has been designed to find a possible new route for the metastasis of cancer cells on the fascia surrounding tumor tissue using a novel technique of trypan blue staining.
Materials and Methods: Tumor tissues were grown in the skin of nude mice after sub-cutaneous inoculation with human lung cancer cells. Trypan blue was recently identified as a dye with specificity for Bonghan ducts (BHDs) and not other tissues, such as blood or lymph vessels or nerves.
Results: We demonstrate that the trypan blue staining technique allows the first visualization of BHDs which are connected to tumor tissues.
Conclusion: Since BHDs are known to make up a circulatory system corresponding to acu puncture meridians or collaterals, we propose that, in addition to the currently known blood or lymph vessels, BHDs on tumor tissue fascia may be a novel pathway for metastasis.
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KEYWORD
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Bonghan duct, cancer, metastasis, trypan blue
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